New Neomycin Sulphate

Description

Neomycin sulfate is a broad-spectrum aminoglycoside antibiotic used to treat various bacterial infections. It works by inhibiting bacterial protein synthesis, leading to bacterial cell death. It’s commonly used in topical applications for skin infections and in oral formulations for gastrointestinal issues or as a pre-surgery bowel preparation.
Key Properties and Uses:
Antibiotic Class: Aminoglycoside.
Mechanism of Action: Binds to bacterial ribosomes, interfering with protein synthesis.
Spectrum of Activity: Effective against both Gram-positive and Gram-negative bacteria.
Common Uses:
Topical: Treats skin infections, prevents infections in minor cuts and wounds.
Oral: Used in hepatic coma treatment, pre-surgery bowel preparation, and for intestinal bacterial infections.
Formulations: Available as creams, ointments, powders, and oral solutions.
Combination Therapies: Often used in combination with other antibiotics like polymyxin B and bacitracin.
Important Considerations:
Absorption:
Neomycin is poorly absorbed from the gastrointestinal tract when taken orally, making it effective for intestinal infections.
Side Effects:
Potential side effects include allergic reactions, hearing problems, and kidney issues, especially with prolonged use or systemic absorption.
Drug Interactions:
Oral neomycin can affect the absorption of other medications like digoxin and vitamin B12.
Not for Viral Infections:
Neomycin is not effective against viral infections like colds or flu.
Resistance:
Like all antibiotics, overuse of neomycin can lead to antibiotic resistance.